Histone H3.2 (H3C15)

Histone H3.2 (H3C15) is a replication-dependent core histone protein encoded by an intronless gene (H3C15/HIST2H3A) located in a histone gene cluster on human chromosome 1[1][2][3][8][9]. It is one of four core histones (H2A, H2B, H3, H4) that together form the nucleosome, the basic structural unit of eukaryotic chromatin, with approximately 146 base pairs of DNA wrapped around a histone octamer. Histone H3.2 plays a central role in the organization and compaction of DNA, limiting accessibility to genetic material. The molecule is subject to numerous post-translational modifications that constitute the 'histone code', influencing DNA-related processes such as transcription, DNA repair, replication, and chromosome stability. This particular variant is not a common direct drug target, but global or site-specific modifications of histone H3 are significant in research on gene regulation and diseases associated with epigenetic dysregulation[1][2][3][9].

Other names

HIST2H3AH3F2H3FMHIST2H3CHIST2H3DH3/nH3/oH3C13H3C14histone cluster 2 H3 family member ahistone H3/mhistone H3/oH3-clustered histone 13H3-clustered histone 14H3-clustered histone 15histone 2 H3aH3a

Not directly drug-targeted; general histone-modifying agents alter histone code to modulate gene expression