Histone H3.7 (H3-7)

Histone H3.7 (H3-7) is a putative member of the histone H3 family involved in the packaging of DNA into nucleosomes, thereby contributing to chromatin structure in eukaryotic cells[1]. The gene is found outside the canonical histone clusters and evidence indicates that while it is transcribed and encodes a full-length protein, residue differences suggest it may be on its way to becoming a pseudogene[1]. Like other histone H3 variants, its core functions (if translated) would include DNA condensation into chromatin and regulation of DNA accessibility for transcription, replication, and repair[1][2]. However, H3-7 is not a well-established unique histone variant, and its gene (HIST2H3PS2) is described as a pseudogene, indicating it likely does not code for an active protein in most contexts[1][4]. No data support this molecule as a drug target, biomarker, or focus of clinical intervention; there are also no known drugs or therapeutic mechanisms specifically acting on it. **Key notes:** - The multiple synonyms and presence of "pseudogene" in major aliases (HIST2H3PS2 = "histone cluster 2, H3, pseudogene 2") indicate this is not an active, functional drug target[1][4]. - Functions and disease roles described are general to the histone H3 family and do not indicate specific H3-7 involvement in pathogenesis or therapy. - Other histone H3 variants, such as H3.3 (gene *H3F3A*, *H3F3B*), are genuine, functional histone proteins involved in epigenetic regulation and human disease (notably pediatric gliomas), but H3-7/HIST2H3PS2 is not among these[2][5]. **Summary:** Histone H3.7 (H3-7, HIST2H3PS2) is best classified as a human pseudogene with no established relevance as a therapeutic target, no direct role in disease or targeted therapy, and no interacting drugs or safety concerns relevant to clinical or translational research[1][4].

Other names

H3-7Histone H3-7H3-2HIST2H3PS2p06H3.7H3.2 histone (putative)histone 2H3pseudogene 2histone H3.2histone HIST2H3PS2histone cluster 2 H3 pseudogene 2