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Histone H4
- Molecular classification
- Histone, Transcription factor, Histone modification
01
Overview
Histone H4 is a core histone protein that is a component of chromatin in eukaryotic cells. It is essential for packaging DNA into nucleosomes and regulating transcription, DNA repair, replication, and chromosome stability. Post-translational modifications (PTMs) on Histone H4, such as acetylation and methylation, play critical roles in gene regulation by altering chromatin structure or recruiting regulatory proteins.
- Other names
- H4F3HIST1H4AHIST1H4A-LHIST2H4A-BHIST4H4
02
Mechanism of action
Epigenetic modulation through chromatin remodeling and histone modification.
03
Biological functions
Packaging DNA into chromatinTranscription regulationDNA repairDNA replicationChromosome stabilityGene regulation
04
Disease associations
CancerOther
05
Safety considerations
Aberrant histone modification patterns can contribute to various diseases.Off-target effects of histone modification inhibitors.
06
Biomarkers
H4K16AcH4K20Me
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