Histone H4 clustered 7 (H4C7)

Histone H4 clustered 7 (H4C7) encodes a replication-dependent histone protein that is a core component of the nucleosome, the primary packaging unit of eukaryotic chromatin. Two molecules each of the four core histones (H2A, H2B, H3, H4) form an octamer, around which DNA is wound. This packaging limits DNA accessibility to the cellular machinery involved in processes such as transcription, replication, repair, and chromosomal stability. H4C7 is intronless, encoded in a large histone gene cluster on chromosome 6, and its transcripts lack polyA tails, instead terminating with a palindromic sequence. Alterations in histone composition, including H4C7, may contribute to diseases such as cancer, with some evidence suggesting a role for H4G (H4C7) in regulating ribosomal DNA transcription in breast cancer[1][2][5][6]. Histones such as H4C7 are not typical therapeutic drug targets or disease biomarkers; rather, they are central chromatin components whose perturbation can have widespread effects on genome function.

Other names

Histone H4-like protein type GH4C7H4/LH4FLHIST1H4GH4/lhistone H4-like protein type GH4 histone family, member Lhistone 1, H4ghistone cluster 1 H4 family member ghistone cluster 1, H4g

not applicable (no direct-acting drugs or mechanism of pharmacological intervention reported)