Histone H4 clustered histone 5 (H4C5)

Histone H4 clustered histone 5 (H4C5) is a member of the core histone family, encoding a highly basic nuclear protein essential for the structural organization of chromatin in eukaryotes[2][1]. Together with histones H2A, H2B, and H3, H4 forms an octamer around which ~146 base pairs of DNA wrap to create the nucleosome, the fundamental repeating unit of chromatin[2][1]. H4C5 is a **canonical, replication-dependent histone** encoded on chromosome 6 within a large histone cluster; its transcripts lack polyA tails, instead containing a palindromic terminator[2]. Variation in H4C5, such as missense or frameshift mutation, has been associated with **syndromic autism spectrum disorder**, intellectual disability, and developmental delay, likely due to disruption in chromatin structure or regulation[2]. Histone H4 (including H4C5) is subject to multiple post-translational modifications (methylation, acetylation, phosphorylation, etc.), which regulate chromatin accessibility, gene transcription, DNA repair, and cell cycle progression[1]. The **protein itself is not considered a direct therapeutic target**; however, broader epigenetic therapy strategies (e.g., HDAC inhibitors) can affect histone H4 function indirectly by modifying its post-translational state[1]. Safety considerations preclude direct targeting, as disruption of core histones is generally cytotoxic.

Other names

Histone H4HIST1H4AHIST1H4BHIST1H4CHIST1H4DHIST1H4EHIST1H4FHIST1H4HHIST1H4IHIST1H4JHIST1H4KHIST1H4LHIST2H4HIST2H4AHIST2H4BHIST4H4H4FJH4FEH4FGH4FBH4FCH4FHH4FIH4FMH4FDH4FKH4FNH4FOH4FAH4C1H4C2H4C3H4C4H4C6H4C8H4C9H4C11H4C12H4C13H4C14H4C15H4C16H4/BH4/CH4/DH4/EH4/GH4/HH4/JH4/KH4/LH4/MH4/NH4/OH4-16TEBIVANED3TEVANED3histone H4H4 histone family, member Jhistone 1, H4ehistone cluster 1 H4 family member ehistone cluster 1, H4e