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Target intelligence / Profile preview
Histone Lysine Demethylase 4 (KDM4)
- Target
- KDM4
- Molecular classification
- Enzyme, Histone modification enzyme, Histone demethylase, Dioxygenase
01
Overview
Histone lysine demethylase 4 (KDM4), also known as the JMJD2 family, is a subfamily of histone demethylases that catalyze the removal of methyl groups from specific lysine residues on histones H3K9 and H3K36. This process is a key epigenetic mechanism regulating chromatin structure and gene expression. Overexpression or amplification of KDM4 is implicated in various cancers, making it a potential therapeutic target.
- Other names
- Jumonji domain-containing protein 2 (JMJD2) familyKDM4AKDM4BKDM4CJMJD2AJMJD2BJMJD2C
02
Mechanism of action
Oxidative demethylation using Fe(II) and alpha-ketoglutarate as cofactors
03
Biological functions
Epigenetic regulationChromatin remodelingGene expression regulationCellular differentiationEmbryonic development
04
Disease associations
CancerProstate cancerColon cancerLung cancerBreast cancerInfertility
05
Safety considerations
Potential for off-target effects due to similarity between KDM4 family membersDisruption of normal histone methylation patterns
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