Histone messenger RNA (Histone mRNA)

Histone messenger RNA (histone mRNA) refers to a unique class of eukaryotic mRNAs that encode canonical histone proteins (such as H1, H2A, H2B, H3, H4) required for DNA packaging into chromatin during S-phase of the cell cycle[1][2][5]. Unlike most mRNAs, histone mRNAs are *not polyadenylated*; instead, their 3′ ends terminate in a conserved stem-loop structure recognized by stem-loop binding protein (SLBP), and require precise 3′ end processing involving specialized RNA elements and factors such as U7 snRNP and CPSF-73[4][7][8][10]. The levels of histone mRNA are tightly cell cycle regulated to ensure a rapid supply during DNA replication and prompt removal at S-phase exit, supporting genomic integrity and chromatin structure[1][2][3][6][10]. While histone mRNA is essential for cell proliferation and chromatin maintenance, it is an intermediate transcript, not a druggable target or receptor, and not considered a therapeutic target. Its abnormal metabolism can indirectly influence diseases associated with chromatin regulation or cell cycle defects, but it is not itself classified as a disease biomarker, direct disease gene, or drug target. ### Additional clarification: - **is_target:** Histone mRNA is not a protein, receptor, or enzyme, but rather a class of non-polyadenylated mRNA transcripts coding for histone proteins[2][5]. It is therefore *not* itself considered a therapeutic target. - **is_incorrect:** The term “Histone mRNA” is not a canonical drug target or biomolecule for therapeutic modulation, but rather a molecular RNA species[2][5]. For structured therapeutic target information, you should refer to the **individual histone proteins** (e.g., "Histone H3") or the **histone mRNA processing machinery** (e.g., SLBP, CPSF-73) if relevant.

Other names

replication-dependent histone mRNAcanonical histone mRNAnon-polyadenylated histone mRNA