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Target intelligence / Profile preview
HIV-1 Envelope Glycoprotein-Mediated Membrane Fusion (HIV-1 Env-mediated Membrane Fusion)
- Target
- HIV-1 Env-mediated Membrane Fusion
- Molecular classification
- Viral Fusion Protein, Viral Envelope Glycoprotein
01
Overview
The membrane fusion process mediated by the HIV-1 envelope glycoprotein (Env) complex is essential for viral entry into host cells. This process involves the interaction of gp120 with CD4 and a coreceptor (CCR5 or CXCR4), leading to conformational changes in gp41 and insertion of the fusion peptide into the target cell membrane. The subsequent formation of a six-helix bundle brings the viral and cellular membranes together, facilitating fusion. This process can be inhibited by peptides like C46, which block the formation of the six-helix bundle.
- Other names
- HIV-1 Membrane FusionHIV-1 Entrygp120/gp41-mediated membrane fusionHIV-1 Env-mediated entry
02
Mechanism of action
C46 peptide binds to the HR1 region of gp41, preventing the formation of the six-helix bundle and inhibiting membrane fusion.
03
Biological functions
Viral entry into host cellsMembrane fusion
04
Disease associations
HIV-1 InfectionAIDS
05
Safety considerations
Potential for viral resistanceImmunogenicity of peptides
06
Interacting drugs
C46 peptide
1 more in the full profile.
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