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Target intelligence / Profile preview
HIV-1 Reverse Transcriptase (NNRTI Binding Site) (NNRTI Binding Site)
- Target
- NNRTI Binding Site
- Molecular classification
- Enzyme, Viral protein, Reverse transcriptase
01
Overview
The NNRTI binding site is a hydrophobic pocket on the p66 subunit of HIV-1 reverse transcriptase. It is the target for non-nucleoside reverse transcriptase inhibitors (NNRTIs), which are allosteric inhibitors that bind to this site and induce conformational changes in RT, thereby inhibiting its enzymatic activity and preventing viral replication. The plasticity of this pocket and the emergence of resistance mutations are major challenges in HIV therapy.
- Other names
- NNRTI pocketReverse Transcriptase NNRTI Binding SiteHIV-1 RT NNRTI Binding Sitep66 subunit NNRTI binding pocket
02
Mechanism of action
Allosteric inhibition of reverse transcriptase
03
Biological functions
Reverse transcription of viral RNAViral replication
04
Disease associations
HIV-1 infectionAIDS
05
Safety considerations
Drug resistance mutationsCross-resistance between NNRTIs
06
Interacting drugs
Nevirapine
3 more in the full profile.
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