HIV-1 Reverse Transcriptase Allosteric Site (HIV-1 RT Allosteric Site)

Allosteric sites on HIV-1 reverse transcriptase (RT) offer alternative targets for anti-HIV drug development. These sites, distinct from the active site, allow inhibitors to modulate enzyme activity through conformational or dynamic changes. Key allosteric sites include the NNRTI binding pocket and newly identified sites like the Incoming Nucleotide Binding, Knuckles, and NNRTI Adjacent sites. Targeting these sites provides opportunities to overcome drug resistance and develop novel anti-HIV therapies.

Other names

Reverse Transcriptase Allosteric SiteHIV RT Allosteric SiteNNRTI Binding PocketIncoming Nucleotide Binding SiteKnuckles SiteNNRTI Adjacent Site399 Site428 SiteRNase H Primer Grip Adjacent Site507 Site

Allosteric inhibition via conformational/dynamic modulation of reverse transcriptase activity.