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Target intelligence / Profile preview
HIV Capsid Protein (CA)
- Target
- CA
- Molecular classification
- Structural protein, Viral protein
01
Overview
The HIV capsid protein, also known as CA or p24, is a major structural component of HIV-1. It forms the conical capsid core that protects the viral RNA genome. Essential for multiple steps in the viral life cycle including assembly, maturation, uncoating, nuclear import and integration. It interacts with numerous host cell factors which influences viral infectivity and sensitivity to antiviral drugs, making it a key target for drug development.
- Other names
- p24HIV-1 Capsid Protein
02
Mechanism of action
Inhibition of capsid assembly/disassembly, binding to capsid protein and interfering with its function
03
Biological functions
Virion assemblyGenome protectionTraffickingNuclear importUncoatingDisassemblyImmune evasion
04
Disease associations
InfectionHIV infectionAIDS
05
Safety considerations
Resistance mutationsGenetic variability
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