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Target intelligence / Profile preview
HIV Envelope Protein (Env)
- Target
- Env
- Molecular classification
- Glycoprotein, Viral protein, Fusion protein
01
Overview
The HIV envelope protein (Env) is a complex, trimeric glycoprotein found on the surface of the human immunodeficiency virus (HIV). It plays a critical role in viral entry into host cells by mediating attachment and fusion with the target cell membrane. Env is initially synthesized as a single precursor polyprotein, gp160, which is cleaved into gp120 (receptor binding) and gp41 (membrane fusion). It is the primary target for neutralizing antibodies and an important focus for vaccine and drug development.
- Other names
- gp160gp120gp41
02
Mechanism of action
Inhibition of gp120 interaction with CD4 receptor, blocking viral entry
03
Biological functions
Viral entryMembrane fusionReceptor bindingImmune evasion
04
Disease associations
HIV infectionAIDS
05
Safety considerations
High variability complicates vaccine designImmune evasionDrug resistance
06
Interacting drugs
BMS-378806
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