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HIV Fusion Process

Molecular classification: Viral Fusion, Viral Entry

Overview

The HIV fusion process is a critical step in the HIV life cycle, enabling the virus to enter and infect host immune cells. This process involves molecular interactions between viral envelope proteins (gp120/gp41) and host cell surface receptors (CD4 and CCR5 or CXCR4), culminating in the merging of the viral envelope with the host cell membrane. Blocking this process halts new infections at an early stage.

Other names: HIV EntryHIV Membrane FusionHIV Envelope Fusion

Mechanism of action

Inhibition of HIV-1 fusion with CD4+ cells by binding to gp41

Biological functions

Viral InfectionMembrane FusionCell Entry

Disease associations

HIV InfectionAIDS

Safety considerations

Injection site reactionsIncreased risk of bacterial pneumonia

Interacting drugs

Enfuvirtide

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