Target intelligence / Profile preview

HIV Integrase Enzyme (Integrase)

Target: Integrase
Molecular classification: Enzyme, Viral protein

Overview

HIV integrase is a 32 kDa viral enzyme essential for the replication of Human Immunodeficiency Virus (HIV). It catalyzes the integration of viral DNA into the host cell genome, a critical step in the retroviral life cycle. This process allows HIV to establish persistent infection and is required for productive viral replication. Inhibition blocks establishment of chronic infection; thus central to modern anti-HIV therapy.

Other names: HIV Integrase

Mechanism of action

Inhibition of viral DNA integration into the host cell genome.

Biological functions

Viral DNA integrationRetroviral replication

Disease associations

InfectionHIV Infection

Interacting drugs

Raltegravir

1 more in the full profile.

Beyond the preview

Go deeper on HIV Integrase Enzyme (Integrase).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on HIV Integrase Enzyme (Integrase).