Target intelligence / Profile preview

HIV Integrase Enzyme (Integrase)

Target: Integrase
Molecular classification: Enzyme, Viral protein

Overview

HIV integrase is a 32 kDa viral enzyme essential for the replication of Human Immunodeficiency Virus (HIV). It catalyzes the integration of viral DNA into the host cell genome, a critical step in the retroviral life cycle. This process allows HIV to establish persistent infection and is required for productive viral replication. Inhibition blocks establishment of chronic infection; thus central to modern anti-HIV therapy.

Other names: HIV Integrase

Mechanism of action

Inhibition of viral DNA integration into the host cell genome.

Biological functions

Viral DNA integrationRetroviral replication

Disease associations

InfectionHIV Infection

Interacting drugs

Raltegravir

1 more in the full profile.

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