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Target intelligence / Profile preview
HIV pol protein (Pol)
- Target
- Pol
- Molecular classification
- Polyprotein, Enzyme, Protease, Reverse Transcriptase, Integrase
01
Overview
The HIV pol protein is a polyprotein encoded by the *pol* gene of the Human Immunodeficiency Virus (HIV), primarily HIV-1. It is essential for viral replication and maturation, as it harbors three key viral enzymes: protease (PR), reverse transcriptase (RT), and integrase (IN). These enzymes are responsible for processing viral proteins, synthesizing DNA from RNA, and integrating the viral genome into host DNA.
- Other names
- HIV polymeraseHIV-1 pol proteinGag-Pol polyprotein precursor
02
Mechanism of action
Inhibition of protease, reverse transcriptase, or integrase activity
03
Biological functions
Viral replicationViral maturationProteolysisReverse transcriptionIntegration of viral DNAAssembly of virions
04
Disease associations
HIV infectionAIDS
05
Safety considerations
Drug resistanceSide effects of antiretroviral therapyViral rebound upon treatment interruption
06
Interacting drugs
Protease inhibitors
2 more in the full profile.
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