Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
HIV Protease (PR)
- Target
- PR
- Molecular classification
- Enzyme, Aspartyl Protease
01
Overview
HIV protease (also known as HIV-1 protease or PR) is a retroviral aspartyl protease that plays an essential role in the life cycle of the Human Immunodeficiency Virus (HIV), which causes AIDS. It is responsible for cleaving newly synthesized polyproteins—specifically Gag and Gag-Pol—at nine distinct sites, producing the mature protein components required for assembling infectious viral particles. Without functional HIV protease, new virions remain immature and non-infectious.
- Other names
- HIV-1 ProteaseRetroviral Aspartyl Protease
02
Mechanism of action
Competitive inhibition of HIV protease active site, preventing polyprotein cleavage.
03
Biological functions
Viral maturationPolyprotein processingProtein hydrolysis
04
Disease associations
InfectionAIDS
05
Safety considerations
Drug resistance (mutations)Metabolic disturbancesSide effects associated with protease inhibitors
06
Interacting drugs
Saquinavir
8 more in the full profile.
Beyond the preview
Go deeper on HIV Protease (PR).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on HIV Protease (PR).