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Target intelligence / Profile preview
HIV Type 1 Aspartic Protease (HIV-1 PR)
- Target
- HIV-1 PR
- Molecular classification
- Enzyme, Aspartic Protease, Retroviral Protease
01
Overview
HIV-1 aspartic protease is a homodimeric retroviral enzyme essential for the HIV-1 life cycle. It cleaves Gag and Gag-Pol polyproteins, releasing mature viral proteins required for virion assembly and infectivity. Inhibition of HIV-1 protease is a key target for antiretroviral therapy. Drug resistance is a common challenge.
- Other names
- HIV-1 proteaseHIV proteasePR
02
Mechanism of action
Competitive inhibition of HIV-1 protease active site, preventing polyprotein processing and viral maturation.
03
Biological functions
Proteolytic cleavageViral maturationGag-Pol polyprotein processing
04
Disease associations
InfectionHIV infectionAIDS
05
Safety considerations
Drug resistance mutationsMetabolic side effects (dyslipidemia, insulin resistance)
06
Interacting drugs
Saquinavir
9 more in the full profile.
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