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Target intelligence / Profile preview
HIV Vif protein (Vif)
- Target
- Vif
- Molecular classification
- Accessory protein, Viral protein, RNA-binding protein
01
Overview
The HIV Vif protein is an accessory protein encoded by the human immunodeficiency virus (HIV) and other lentiviruses. It plays a critical role in viral replication and infectivity, primarily by counteracting host cellular defense mechanisms. Its primary function is to neutralize the antiviral activity of host APOBEC3 family enzymes by recruiting an E3 ubiquitin ligase complex to degrade them. Vif also functions as an RNA-binding protein.
- Other names
- Viral infectivity factor
02
Mechanism of action
Recruits Cullin5-based E3 ubiquitin ligase complex to degrade APOBEC3 proteins.
03
Biological functions
APOBEC3 antagonismInhibition of host antiviral defenseUbiquitinationProtein degradationViral replicationRNA bindingRegulation of viral assembly
04
Disease associations
HIV infectionAIDS
05
Safety considerations
Inhibition of Vif may lead to increased APOBEC3 activity and viral hypermutation.Resistance to Vif inhibitors may develop through mutations in Vif or APOBEC3 proteins.
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