HIVEP zinc finger 2 (HIVEP2)

HIVEP zinc finger 2 (HIVEP2) is a large human zinc finger transcription factor that binds directly to DNA, including enhancer elements of the major histocompatibility complex (MHC) and the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR). It contains multiple C2H2-type zinc finger domains and is known by several aliases, reflecting its roles in immune regulation and transcriptional control. HIVEP2 can downregulate the NF-κB pathway, a key transcriptional pathway for immune and inflammatory responses, and has been implicated in neural and developmental functions. Pathogenic variants in HIVEP2 cause a recognizable neurodevelopmental syndrome characterized by intellectual disability, developmental delay, and behavioral abnormalities. There are no approved drugs targeting HIVEP2 directly, and it is principally studied as a transcriptional regulator rather than a traditional drug target. Key information is deduced from UniProt, NCBI Gene, and relevant scientific literature. No specific drugs, mechanisms of action, or biomarker roles are described in current high-quality sources.

Other names

Transcription factor HIVEP2HIV-EP2MIBP1ZAS2Schnurri-2ZNF40BHuman immunodeficiency virus type I enhancer-binding protein 2MHC-binding protein 2c-myc intron binding protein 1SHN2MRD43