HIVEP zinc finger protein 3 (HIVEP3)

HIVEP zinc finger protein 3 (HIVEP3) is a large, nuclear transcription factor belonging to the ZAS family, characterized by multiple C2H2-type zinc finger domains, acid-rich (ZAS) domains, and serine/threonine-rich regions[1][2][6]. It binds specific DNA motifs, notably the kappa-B motif in promoters/enhancers of immune-related genes and viruses, including HIV, and plays a key regulatory role in gene expression controlled by the NF-kappaB transcriptional pathway[1][3]. HIVEP3 is also essential in bone biology by acting as a negative regulator of osteoblast differentiation and bone formation, repressing osteogenesis via direct modulation of ERK signaling and promoting degradation of the osteogenic master regulator Runx2[2]. In immune cell development, it binds recombination signal sequences involved in V(D)J recombination, affecting immunoglobulin and T-cell receptor gene rearrangement. Dysregulation of HIVEP3 has been implicated in skeletal disorders, such as Meckel syndrome and osteochondrodysplasia, and its inhibition has been proposed as a therapeutic strategy for osteoporosis[2][1][3][4].

Other names

Human immunodeficiency virus type I enhancer-binding protein 3Transcription factor HIVEP3Kappa-B and V(D)J recombination signal sequences-binding proteinKappa-binding protein 1Zinc finger protein ZAS3KBP-1KBP1KRCSHN3Schnurri-3ZAS3ZNF40CFLJ16752KIAA1555

Not applicable for approved drugs; inhibition of HIVEP3 is theoretically proposed to enhance bone formation by relieving suppression of osteoblast differentiation and ERK signaling