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HIVEP2 divergent transcript (HIVEP2-DT)

Target
HIVEP2-DT
Molecular classification
Long non-coding RNA (lncRNA), Other
01

Overview

HIVEP2 divergent transcript (HIVEP2-DT), also known as PILA or PRMT1-interacting lncRNA, is a long non-coding RNA gene located on human chromosome 6. It is recognized by gene databases (e.g., Ensembl: ENSG00000232618, HGNC:55724) and shares genomic proximity with the HIVEP2 protein-coding locus but does not encode a protein. Unlike HIVEP2, which functions as a zinc finger transcription factor and is implicated in intellectual disability, HIVEP2-DT has not been documented as a direct molecular or therapeutic target, nor does it have established roles in diseases or as a biomarker. Its functional annotation is minimal, and its only suggested role, based on its alias, is potential interaction with PRMT1, but details are lacking in public resources as of mid-2025. Key distinctions: - HIVEP2-DT is an lncRNA, not a protein, receptor, enzyme, transporter, or canonical drug target. - Scarce scientific literature describes its function or any clinical relevance; it is distinct from the protein-coding HIVEP2 gene, which has established disease links. If you seek information on the protein-coding HIVEP2 (HIVEP zinc finger 2; synonym: Schnurri-2), see those entries for disease associations and biological functions.

Other names
PILAPRMT1-interacting lncRNA
02

Mechanism of action

None identified for drugs (as no drugs interact with this lncRNA)

03

Biological functions

No explicitly described biological functions for HIVEP2-DT in curated databases or literature. Its alias "PRMT1-interacting lncRNA" suggests potential involvement in chromatin regulation or interaction with the protein arginine methyltransferase 1 (PRMT1), but direct experimental evidence is lacking or not described.
04

Disease associations

There are no established disease associations or roles for HIVEP2-DT in major genetic or disease databases. This distinguishes it from the protein-coding HIVEP2 gene, which is implicated in neurodevelopmental disorders.

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