HLA-A*03:01–CD45 peptide complex (None established; typically referred to as peptide/HLA-A*03:01 complex)

The HLA-A*03:01–CD45 peptide complex consists of a CD45-derived peptide presented by the HLA-A*03:01 molecule on the cellular surface. HLA-A*03:01 is a class I MHC molecule that binds intracellular peptides and displays them for recognition by CD8+ T cell receptors. Specific peptide/HLA-A*03:01 complexes are central to immune discrimination in cancer, infection, and autoimmunity. Their therapeutic utility arises in cancer immunotherapy, where T cell receptors or engineered antibodies can selectively target tumor cells displaying neoantigenic peptides in this context, leading to immune-mediated cell death. The molecular specificity, structural stability, and clinical relevance depend on both the peptide sequence and the HLA allele, making this complex a key immunological target in personalized medicine and immuno-oncology.

Other names

Peptide/HLA-A*03:01 complexHLA-A*03:01–peptide complexHLA class I peptide complex (specific for A*03:01)MHC-I CD45 peptide complex

Recognition by engineered T cell receptors (TCR) leading to T cell activation and cytotoxicity against peptide-presenting cells Binding by TCR-mimic antibodies, facilitating immune depletion of target cells