HLA-A*24:02-restricted T-cell receptor complex (HLA-A*24:02 TCR) (HLA-A*24:02 TCR)

The HLA-A*24:02-restricted T-cell receptor (TCR) complex is a multi-subunit transmembrane signaling assembly found on T-lymphocytes that specifically recognizes antigenic peptides presented by the HLA-A*24:02 MHC class I molecule [1]. This HLA allele is one of the most common in East Asian populations, particularly in Japan, where it serves as a critical restriction element for the presentation of tumor-associated antigens [1]. The TCR complex consists of a variable alpha/beta heterodimer that confers antigen specificity and a set of invariant CD3 subunits (gamma, delta, epsilon, and zeta) that facilitate signal transduction [3]. In modern oncology, this complex is the cornerstone of TCR-engineered T-cell (TCR-T) therapies, where patient T-cells are modified to express a high-affinity TCR specific for antigens like WT1 or NY-ESO-1 presented by HLA-A*24:02 [2]. Upon engagement with the target peptide-MHC complex, the TCR triggers a robust immune response, leading to the targeted destruction of malignant cells through cytotoxic granule release and cytokine production [4]. The development of these receptors requires rigorous screening to ensure high specificity and to prevent cross-reactivity with similar peptides in healthy tissues, which can lead to severe adverse events [4].

Other names

HLA-A24-restricted TCRA*2402-restricted T-cell receptorHLA-A*2402-restricted T-cell receptor complexMHC class I-restricted T-cell receptor

Recognition of specific peptide-HLA-A*24:02 complexes on target cells, triggering T-cell activation and cytotoxic effector functions [3, 4].