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Target intelligence / Profile preview
HLA Class I Histocompatibility Antigen A Alpha Chain (HLA-A)
- Target
- HLA-A
- Molecular classification
- Transmembrane glycoprotein, MHC Class I molecule, Receptor
01
Overview
The HLA class I histocompatibility antigen, A alpha chain (HLA-A), is a major component of the human leukocyte antigen (HLA) system. It is a transmembrane protein that presents endogenous peptides to CD8+ cytotoxic T lymphocytes, playing a crucial role in immune surveillance and adaptive immunity. High allelic diversity contributes to immune system variability and influences susceptibility to diseases.
- Other names
- HLA-A alpha chainMHC class I antigen A alpha chainHuman Leukocyte Antigen A
02
Mechanism of action
N/A
03
Biological functions
Antigen presentationImmune surveillanceT cell activationAdaptive immunity
04
Disease associations
Autoimmune diseasesInfectious diseasesCancerTransplant rejection
05
Safety considerations
Transplant rejectionGraft-versus-host disease (GVHD)Adverse immune reactions
06
Biomarkers
HLA-A allele type (for transplant compatibility and disease susceptibility)Peptide-HLA-A complex
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