HLA complex group 4B pseudogene (HCG4B)

HLA complex group 4B (HCG4B) is a long non-coding RNA gene located in the human major histocompatibility complex (MHC) region and is annotated as a pseudogene[4][5]. It does not encode a functional receptor or protein and is not a recognized therapeutic target. The locus is distinct from protein-coding HLA genes (such as HLA-B) that play important roles in immune response and disease, and confusion with those targets should be avoided[2][3]. HCG4B may have minor or uncharacterized roles in gene regulation within the MHC region, but no definitive biological or disease role has been established. It is identified primarily by sequence and genomics databases and has several alternate names, most relating to its pseudogene status or genomic location. Key considerations: - HCG4B is non-protein coding and not a classical molecular target. - No drugs or biomarkers are associated with HCG4B. - It is sometimes misclassified as a functional HLA gene due to naming similarity; confirm functional context when extracting data. - Use care not to conflate HCG4B with true therapeutic MHC class I or II HLA proteins (e.g., HLA-B)[2][3].

Other names

HCGIV-6HCGIV.5HCGIV-06bCX67J3.3Em:AB023056.16bPG309N1.1bQB90C11.3HCGIV-6 pseudogeneHCG4P6