HLA complex P5 long noncoding RNA (HCP5)

HCP5 (HLA complex P5) is a human-specific long noncoding RNA gene located in the MHC class I region of chromosome 6. It comprises sequence elements from HLA class I gene fragments and endogenous retroviral (ERV) sequence, acting mainly as a regulatory noncoding RNA. HCP5 is involved in transcriptional regulation, binding transcription factors, enhancers, and chromatin remodelers. It interacts with microRNAs and influences immune checkpoint responses in cancers, making it relevant for disease association studies. Traditional annotation as "cytochrome c pseudogene 5" is a legacy label; functionally, HCP5 is not an enzyme, receptor, or classical drug target, but a regulatory lncRNA associated with cancer, autoimmunity, and infection[1][2][3].

Other names

HCP5P5-1Cytochrome c pseudogene 5CYCSP5

Not applicable (no drugs targeting HCP5 known; possible future mechanism could involve modulation of lncRNA activity, microRNA sponging, or chromatin state alteration)