Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
HLA-DPB1*04
- Target
- HLA-DPB1*04
- Molecular classification
- MHC Class II, Receptor
01
Overview
HLA-DPB1*04 refers to a specific allele of the HLA-DPB1 gene, which encodes the beta chain of the HLA-DP molecule—a member of the major histocompatibility complex (MHC) class II family. The primary function of this molecule is to present peptide antigens derived from extracellular proteins to CD4+ T cells, thereby initiating and regulating immune responses. Variants like HLA-DPB1*04 play roles in susceptibility/protection for autoimmune diseases, response kinetics after vaccination/infection (e.g., hepatitis B), risk stratification for transplant outcomes due to donor-specific antibody formation, and shaping overall immunopeptidome diversity. HLA-DPB1*04-restricted presentation refers specifically to how this MHC class II variant binds select peptides for display on APC surfaces, influencing downstream adaptive immune recognition events based on its unique structural features and expression profile determined by genetic background.
- Other names
- HLA-DP beta chain allele *04DPB1*04
02
Mechanism of action
Modulation of antigen presentation to CD4+ T cells
03
Biological functions
Antigen presentationT cell activationImmune response regulationSelf-recognitionTolerance
04
Disease associations
Autoimmune diseasesTransplant rejectionInfection susceptibilityVaccine response
05
Safety considerations
Potential for altered immune responsesRisk of autoimmunityTransplant rejection
06
Biomarkers
rs9277534Donor-specific antibodies
Beyond the preview
Go deeper on HLA-DPB1*04.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on HLA-DPB1*04.