HLA-DQB1 antisense RNA 1 (HLA-DQB1-AS1)

HLA-DQB1 antisense RNA 1 (HLA-DQB1-AS1) is a long non-coding RNA gene located adjacent to the protein-coding HLA-DQB1 gene in the human major histocompatibility complex (MHC) class II region. HLA-DQB1-AS1 does not code for a protein but exerts regulatory functions by binding to specific RNA-binding proteins, notably ZRANB2, to enhance cell proliferation and inhibit programmed cell death (apoptosis). Its upregulation is implicated in the progression of several cancers, particularly hepatocellular carcinoma, and has also been studied in the context of autoimmune and immune-mediated diseases. HLA-DQB1-AS1 exemplifies a growing class of disease-associated lncRNAs with potential utility as prognostic biomarkers and, potentially, as novel therapeutic targets[2][4][5][6][7].

Other names

HLA-DQB1 antisense RNA 1 (non-protein coding)XXbac-BPG254F23.5HLA-DQB1-AS1HLA-DQB1-AS1 RNA[7]

Interacts directly with RNA-binding proteins (ZRANB2) to promote cell proliferation and inhibit apoptosis[2][4][5] May act as a regulatory lncRNA in disease-associated gene expression[6]