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HLA-DRβ1 Protein Containing Arginine at Position 74 (HLA-DRβ1-Arg74)
- Target
- HLA-DRβ1-Arg74
- Molecular classification
- Major Histocompatibility Complex (MHC) class II, Immune Receptor
01
Overview
HLA-DRβ1-Arg74 refers to a specific variant of the HLA-DRβ1 protein, characterized by an arginine at position 74. This variant is associated with increased risk for several autoimmune diseases, including type 1 diabetes, autoimmune thyroid disease, Graves' disease, and Hashimoto's thyroiditis. It plays a critical role in antigen presentation and immune response regulation by influencing peptide binding properties. Targeting this molecule with compounds like cepharanthine may offer therapeutic benefits by blocking harmful autoimmune responses.
- Other names
- HLA-DRβ1 Chain with Arginine at Position 74HLA-DRB1*0301 with Arg74
02
Mechanism of action
Blocking peptide binding and presentation to T-cells, potentially reducing autoimmune responses.
03
Biological functions
Antigen PresentationImmune Response Regulation
04
Disease associations
Autoimmune DiseasesType 1 DiabetesAutoimmune Thyroid DiseaseGraves' DiseaseHashimoto's Thyroiditis
05
Safety considerations
Potential challenges may include specificity and efficacy in targeting autoimmune diseases without compromising the immune system's ability to respond to other antigens.
06
Interacting drugs
Cepharanthine
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