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Target intelligence / Profile preview
HLA-E expressing autoreactive T cell (N/A)
- Target
- N/A
- Molecular classification
- T cell, CD8+ T cell, Cytotoxic T Lymphocyte (CTL), Immune cell
01
Overview
HLA-E expressing autoreactive T cells are a subset of CD8+ T cells that recognize self-antigens presented by the non-classical MHC molecule HLA-E. These cells can contribute to both immune regulation and autoimmunity. HLA-E's limited polymorphism makes it an attractive target for immunotherapies, but careful consideration is needed to mitigate potential autoimmune side effects.
- Other names
- Autoreactive T cell restricted by HLA-EHLA-E restricted autoreactive CD8+ T cell
02
Mechanism of action
Redirects T cell cytotoxicity towards cells expressing specific HLA-E-peptide complexes; Modulation of NKG2A/CD94 mediated inhibition of T cells.
03
Biological functions
Immune responseCytotoxicityAntigen recognitionT cell receptor (TCR) signalingHLA-E mediated antigen presentationAutoreactivity
04
Disease associations
AutoimmunityCancer (immunosuppression)Infection (immune evasion)
05
Safety considerations
Off-target cytotoxicityCytokine release syndromeOn-target, off-tumor toxicity in HLA-E targeted therapiesAutoimmune complications
06
Interacting drugs
Bispecific antibodies targeting HLA-E
2 more in the full profile.
07
Biomarkers
HLA-E expression levelsFrequency of autoreactive T cellsTCR clonalityNKG2A/CD94 expression levels
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