Homeobox protein goosecoid-2 (GSC2)

Homeobox protein goosecoid-2 (GSC2) is a DNA-binding transcription factor that may play a role in mammalian development, potentially regulating its own transcription and binding the bicoid consensus sequence TAATCC[3][4]. GSC2 is encoded on chromosome 22q11, within a region deleted in Velocardiofacial syndrome and DiGeorge syndrome, which are developmental disorders affecting craniofacial and cardiac structures[3]. Expression is limited in adult tissues and more active in early development[3]. There is little data on specific biochemical function, targetability, or involvement in disease outside its putative role in these deletion syndromes. Key notes: - GSC2 is *distinct* from the classical Goosecoid (GSC) gene that is crucial for organizer function in vertebrate embryogenesis[1][2]; - GSC2's molecular function and disease relevance are comparatively underexplored, and it is not a recognized therapeutic target in drug development databases[3][4]; - GSC2 does *not* have documented drug interactions, biomarker utility, or safety/pharmacologic profiles.

Other names

Goosecoid homeobox 2Homeobox protein goosecoid-2GSCLGSC-LHomeobox protein goosecoid-like