Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Homeobox protein Hox-A13 (HOXA13)
- Target
- HOXA13
- Molecular classification
- Transcription factor, Homeodomain protein
01
Overview
Homeobox protein Hox-A13 (HOXA13) is a sequence-specific DNA-binding transcription factor belonging to the homeobox gene family, critical in vertebrate embryonic development. It controls the formation of limbs, urinary tract, and reproductive organs by regulating expression of key developmental genes. Mutations or polyalanine expansions in HOXA13 cause hand-foot-genital syndrome, a condition characterized by malformations in limbs and urogenital tract. In addition, chromosomal rearrangements involving HOXA13 are associated with certain leukemias, and abnormal HOXA13 expression is implicated in the pathogenesis of Barrett's esophagus, a precursor to esophageal cancer[1][2][3][5].
- Other names
- Homeo box 1JHomeo box A13HOX1HOX1JHox-1JTranscription factor HOXA13homeobox protein HOXA13HXA13_HUMAN
02
Biological functions
Regulation of gene expressionEmbryonic morphogenesisDiferentiationLimb developmentDevelopment of urinary tract and reproductive system
03
Disease associations
CancerDevelopmental disorders (hand-foot-genital syndrome, hand-foot-uterus syndrome)
04
Safety considerations
Disruption/mutation can lead to severe developmental syndromes (e.g., limb and genitourinary malformations)Aberrant expression linked to oncogenic transformation and Barrett’s esophagus progression
05
Biomarkers
HOXA13 expression for hand-foot-genital syndrome diagnosisHOXA13 alterations in certain leukemias via chromosomal translocation
Beyond the preview
Go deeper on Homeobox protein Hox-A13 (HOXA13).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Homeobox protein Hox-A13 (HOXA13).