Homeobox protein Hox-A2 (HOXA2)

Homeobox protein Hox-A2 (HOXA2) is a sequence-specific DNA-binding transcription factor essential for embryonic development in vertebrates, particularly in determining cell positional identity along the anterior-posterior axis. HOXA2 regulates morphogenesis and differentiation, and is critical for correct placement and formation of the lower and middle face, middle ear, and hindbrain segments. Mutations in HOXA2 are known to cause developmental syndromes such as microtia, hearing impairment, and cleft palate[1][2][3][7][8]. There is no current evidence that HOXA2 directly serves as a drug target or biomarker in clinical practice.

Other names

HOX1KHomeobox protein Hox-1KMCOHIhomeobox protein Hox-1Khomeobox A2