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Target intelligence / Profile preview
Homeobox protein Hox-B1 (HOXB1)
- Target
- HOXB1
- Molecular classification
- Transcription factor
01
Overview
Homeobox protein Hox-B1 is a highly conserved sequence-specific transcription factor encoded by the HOXB1 gene in humans. It belongs to the homeobox gene family and is part of the HOXB gene cluster on chromosome 17. Hox-B1 plays a crucial role in morphogenesis by providing cells with specific positional identities along the anterior-posterior axis during development, especially in anterior body structures. Dysfunction of HOXB1 has been associated with developmental disorders affecting cranial nerve formation and facial movement. HOXB1 interacts with other regulatory proteins such as PBX1 to exert its transcriptional functions[1][2][3][6].
- Other names
- HOXB1HOX2IHCFP3HOX2Hox-2.9Homeobox protein Hox-2IHomeobox protein Hox-B1
02
Biological functions
MorphogenesisSequence-specific DNA bindingTranscriptional regulationNervous system developmentProviding positional identity to cells along the anterior-posterior axis
03
Disease associations
Congenital hereditary facial paralysisFacial paresis, hereditary congenital, 3Congenital hereditary facial paralysis-variable hearing loss syndrome[2]
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