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Homeobox protein Hox-B13
- Molecular classification
- Transcription factor, Homeobox transcription factors
01
Overview
Homeobox protein Hox-B13 is a sequence-specific transcription factor essential for embryonic development and tissue homeostasis. It regulates gene expression through its homeodomain and MEIS interacting domains. HOXB13 plays a role in skin development, body patterning, prostate development, and tumor suppression. Germline mutations, particularly G84E, are strongly associated with increased risk for hereditary prostate cancer due to impaired regulation of target gene expression.
- Other names
- HXB13_HUMANPSGDhomeobox B13
02
Mechanism of action
Modulates androgen receptor (AR) signaling pathways; acts as an AR repressor. Can activate or repress transcription of AR target genes.
03
Biological functions
Development of skinBody patterning along the anterior-posterior axisProstate developmentTumor suppressionTranscriptional regulationSequence-specific DNA binding
04
Disease associations
CancerHereditary prostate cancer
05
Safety considerations
Germline mutations increase prostate cancer risk but do not guarantee disease; penetrance varies.Aberrant HOXB13 function may promote uncontrolled cell proliferation
06
Biomarkers
HOXB13 G84E/rs138213197 (for prostate cancer risk assessment)
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