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Target intelligence / Profile preview
Homeobox protein Hox-B3 (HOXB3)
- Target
- HOXB3
- Molecular classification
- Transcription factor
01
Overview
Homeobox protein Hox-B3 (HOXB3) is a sequence-specific transcription factor in the Antp homeobox family encoded by the HOXB3 gene on chromosome 17q21.32[1][2][7][9]. It plays a vital role in developmental processes by providing positional identity to cells during embryogenesis and regulating genes necessary for cell differentiation[4][6][9]. Aberrant expression has been implicated in several cancers, particularly as a marker in acute myeloid leukemia[1][2].
- Other names
- HOX2HOX2GHox-2.7homeobox protein Hox-2.7homeobox protein Hox-2Ghomeo box 2G
02
Mechanism of action
Drugs targeting HOXB3 would typically function through modulation of gene transcription, interfering with or promoting its DNA-binding activity as a transcription factor (inference based on the role)
03
Biological functions
Sequence-specific transcription regulationDevelopmental processes, embryonic patterningCell differentiation
04
Disease associations
Cancer (including acute myeloid leukemia, lung cancer, stomach cancer, breast cancer)
05
Safety considerations
No specific safety concerns or therapeutic challenges documented in the search results; targeting transcription factors such as HOXB3 may pose risks due to the wide role in development and cellular differentiation (inference)
06
Biomarkers
Increased expression of HOXB3 is associated with a subset of acute myeloid leukemia and may serve as a biomarker for this disease
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