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Target intelligence / Profile preview
Homeobox protein Hox-C13 (HOXC13)
- Target
- HOXC13
- Molecular classification
- Transcription factor, DNA binding protein
01
Overview
Homeobox protein Hox-C13, encoded by the HOXC13 gene, is a member of the homeobox family of transcription factors that bind DNA in a sequence-specific manner to regulate gene expression. It plays a key role in morphogenesis, specifically in hair follicle and nail development, and controls the expression of hair-specific genes such as FOXQ1. HOXC13 is implicated in the pathogenesis of certain cancers and genetic disorders like ectodermal dysplasia. Mammals possess four homeobox clusters (HOXA, HOXB, HOXC, HOXD), and HOXC13 is located in the HOXC cluster on chromosome 12.
- Other names
- HOX3HOX3GECTD9NUP98/HOXC13homeo box 3Ghomeobox protein Hox-3G
02
Mechanism of action
Not applicable for approved drugs; theoretical mechanisms would include modulation of gene expression pathways (e.g., inhibition of transcriptional activity by small molecules or peptides if a drug existed)
03
Biological functions
Hair follicle differentiationRegulates expression of hair-specific genes (including FOXQ1)MorphogenesisSequence-specific DNA bindingRNA polymerase II-specific transcription activation
04
Disease associations
Cancer (acute myeloid leukemia, melanoma, cervical cancer, oral cavity cancer, hemangioblastoma)Ectodermal dysplasia, hair/nail type
05
Safety considerations
Transcription factors are widely expressed and critical for developmental processes; targeting them can impact a broad range of essential cellular activities, raising concerns for off-target and developmental toxicity
06
Biomarkers
HOXC13 mutations and aberrant expression may act as diagnostic or prognostic biomarkers in cancers and ectodermal dysplasia
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