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Target intelligence / Profile preview
Homeobox protein Hox-C5 (HOXC5)
- Target
- HOXC5
- Molecular classification
- Transcription factor
01
Overview
Homeobox protein Hox-C5 is a sequence-specific transcription factor encoded by the HOXC5 gene in humans. It belongs to the homeobox family, which consists of highly conserved proteins involved in regulating the patterns of anatomical development (morphogenesis) during embryogenesis in multicellular organisms. HOXC5 provides cells with positional identities along the anterior-posterior axis during development and is a part of the HOXC gene cluster located on chromosome 12[1][2][5]. While some studies link HOXC5 to cellular proliferation and apoptosis, especially via pathways such as Wnt/β-catenin, current evidence does not indicate that it is a direct therapeutic target of any approved drug[4].
- Other names
- HOXC5HOX3DHomeobox protein CP11Homeobox protein Hox-3DCP11HOX3homeobox protein Hox-C5homeo box C5homeobox protein CP11homeobox protein Hox-3D
02
Biological functions
Regulation of developmental processesCell differentiationMorphogenesisControl of gene expression during embryonic development
03
Disease associations
Cancer (implicated in cancer through association with proliferation and apoptosis signaling pathways)Other (may play roles in other developmental diseases)
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