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Homeobox protein Hox-C8 (HOXC8)
- Target
- HOXC8
- Molecular classification
- Transcription factor, Homeobox protein (antennapedia class), DNA-binding protein
01
Overview
Homeobox protein Hox-C8 is a sequence-specific DNA-binding transcription factor encoded by the HOXC8 gene in humans. It belongs to the homeobox gene family, which is critical for morphogenesis and embryonic development across metazoans. HOXC8 regulates gene expression during development and is notably implicated in cartilage differentiation and nerve growth. Aberrant expression of HOXC8 has been associated with certain cancers (such as epithelial ovarian cancer) and developmental disorders[1][7][9].
- Other names
- HOX3HOX3Ahomeobox C8
02
Biological functions
MorphogenesisRegulation of cartilage differentiationPromotion of nerve growthRegulation of gene transcription
03
Disease associations
Cancer (notably epithelial ovarian cancer, possible involvement in neurofibromatosis type 1)Cartilage disorders (including chondrodysplasias)Other (developmental disorders)
04
Safety considerations
Potential oncogenic activity when dysregulatedpossible involvement in developmental anomalies
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