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Target intelligence / Profile preview
Homeobox protein Hox-D11 (HOXD11)
- Target
- HOXD11
- Molecular classification
- Transcription factor
01
Overview
Homeobox protein Hox-D11 (HOXD11) is a sequence-specific transcription factor encoded by the HOXD11 gene, part of the homeobox gene family, which regulates morphogenesis in multicellular organisms[1][3][6]. HOXD11 is clustered on chromosome 2 in humans and coordinates developmental processes, particularly in axial skeleton and limb patterning and organogenesis, by providing cells with positional identities along the anterior-posterior axis[1][3][6]. Deletion or mutation leads to developmental defects of limbs and genitalia, and altered HOXD11 expression or mutation has been implicated in a variety of cancers[2][3].
- Other names
- HOX4HOX4FHox-4.6Homeobox D11homeo box 4FHomeobox protein Hox-4FHomeobox gene D11
02
Biological functions
MorphogenesisAxial skeleton developmentLimb developmentKidney developmentNervous system developmentSequence-specific DNA binding
03
Disease associations
Congenital limb abnormalitiesGenital abnormalitiesStomach cancerMelanomaNeuroblastomaOvarian cancerBone cancerLung cancerEwing's sarcomaOsteoarthritis
04
Safety considerations
No direct safety issues as a therapeutic target, but loss of function or cluster deletion is associated with severe congenital abnormalities[1][3][2].
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