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Target intelligence / Profile preview
Homeobox protein Hox-D3 (HOXD3)
- Target
- HOXD3
- Molecular classification
- Transcription factor, Homeobox protein
01
Overview
Homeobox protein Hox-D3 (HOXD3) is a sequence-specific transcription factor belonging to the homeobox family, a group of highly conserved developmental regulators involved in morphogenesis across multicellular organisms[1][2][3][7]. HOXD3 is located on human chromosome 2q31-2q37 and is one gene of the HOXD gene cluster[1]. It specifies cellular positional identity during embryogenesis and regulates processes such as cell adhesion and gene expression[1][7]. Deletion of the HOXD gene cluster or its 5′ end is associated with severe limb and genital abnormalities[1]. Dysregulation of HOXD3 is implicated in cancer, including promoting colorectal cancer growth and roles in hepatocellular carcinoma progression[6][8]. No drugs are currently listed as direct interactors.
- Other names
- HOXD3HOX1DHOX4AHox-4.1Homeobox protein Hox-4AHOX4homeobox D3homeo box D3Hox-4Ahomeobox protein Hox-D3
02
Biological functions
Regulation of morphogenesisRegulation of cell adhesionSequence-specific DNA bindingRegulation of gene expression
03
Disease associations
Cancer (notably colorectal cancer and hepatocellular carcinoma)Developmental disorders (limb and genital abnormalities due to deletions)
04
Safety considerations
Potential for developmental abnormalities if targeted or dysregulatedOncogenic potential in some cancers
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