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Target intelligence / Profile preview
Homeobox protein NK-3 homolog 1 (NKX3.1) (NKX3.1)
- Target
- NKX3.1
- Molecular classification
- Transcription factor, Homeobox protein, Tumor-associated antigen
01
Overview
- Other names
- Undisclosed tumor-associated antigen 2Undisclosed TAA 2NK3 homeobox 1NKX3-1NKX3ABAPX2
02
Mechanism of action
The target is delivered via an mRNA-lipoplex vaccine (BNT112) which, upon intravenous administration, leads to the expression of the NKX3.1 protein in lymphoid tissues. This expression triggers the activation and expansion of antigen-specific CD4+ and CD8+ T cells, which then recognize and eliminate tumor cells expressing the NKX3.1 antigen.
03
Biological functions
Transcription regulationProstate developmentCell differentiationTumor suppression
04
Disease associations
Prostate cancerProstatic adenocarcinoma
05
Safety considerations
Potential for autoimmune prostatitis (due to expression in normal prostate tissue)Infusion-related reactions (common with liposomal mRNA delivery)Cytokine release syndrome (low risk but monitored in immunotherapy)
06
Interacting drugs
BNT112 (Prostate Cancer Vaccine)
07
Biomarkers
NKX3.1 expression (IHC)PSA levelsAntigen-specific T-cell response (ELISpot)
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