Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Homeobox protein Nkx-2.6 (NKX2-6)
- Target
- NKX2-6
- Molecular classification
- Transcription factor, Homeobox gene family
01
Overview
Homeobox protein Nkx-2.6 (NKX2-6) is a DNA-binding transcription factor belonging to the NK-2 homeobox family, and is a vertebrate homolog of Drosophila 'tinman.' It functions as a transcriptional activator and plays a crucial role, together with NKX2-5, in embryonic development of both the pharynx and the heart, particularly cardiac morphogenesis. Mutations in NKX2-6 have been associated with some forms of congenital heart defects, such as conotruncal heart malformations and persistent truncus arteriosus. However, it is not considered an established therapeutic drug target[1][5][7].
- Other names
- NK2 homeobox 6NKX2FCSX2NKX4-2Homeobox protein NK-2 homolog Ftinman (Drosophila) homologCTHMhomeobox protein NKX2.6tinman homologtinman paralogNK2 transcription factor related, locus 6
02
Biological functions
DNA-binding transcription factor activity[1][7]Embryonic development of the heart and pharynx[1][2][5][7]Transcriptional activation[7]Regulation of cell differentiation[4]
03
Disease associations
Congenital heart defects (e.g., conotruncal heart malformations, persistent truncus arteriosus)[1]Other: Roles in embryonic development but no direct evidence for major adult disease involvement
Beyond the preview
Go deeper on Homeobox protein Nkx-2.6 (NKX2-6).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Homeobox protein Nkx-2.6 (NKX2-6).