Homeodomain Interacting Protein Kinase 2

Homeodomain-interacting protein kinase 2 (HIPK2) is a serine/threonine protein kinase that plays a crucial role in regulating gene expression, apoptosis, and cell cycle control. It is activated by genotoxic stress and functions as a tumor suppressor by promoting apoptosis, inhibiting angiogenesis, and preventing tumor invasion and metastasis. HIPK2 primarily modulates the activity of transcription factors, particularly p53, through phosphorylation. Altered expression or splicing variants of HIPK2 are implicated in various cancers, highlighting its complex role in tumorigenesis.

Other names

HIPK2

HIPK2 modulates the activity of transcription factors (e.g., p53) through phosphorylation, impacting gene expression related to apoptosis, cell cycle control, and DNA damage response.