Homeodomain-interacting protein kinase 3 mRNA 3′ untranslated region (HIPK3 mRNA 3′UTR) (HIPK3 mRNA 3′UTR)

The Homeodomain-interacting protein kinase 3 (HIPK3) mRNA 3′ untranslated region (3′UTR) is a critical regulatory segment of the HIPK3 transcript that governs the stability and translation of the HIPK3 protein (UniProt Q9H422). HIPK3 is a serine/threonine kinase involved in diverse cellular processes, including apoptosis, glucose metabolism, and the cell cycle. The 3′UTR serves as a primary docking site for various microRNAs (miRNAs), such as miR-193a-3p and miR-338-3p, which post-transcriptionally repress HIPK3 expression (PubMed: 25823897, 21880712). Dysregulation of this regulatory axis is implicated in several pathologies; for instance, reduced miRNA binding or 3′UTR mutations can lead to HIPK3 overexpression, promoting oncogenesis and chemoresistance in various cancers (PubMed: 25823897). In metabolic contexts, the HIPK3 3′UTR-miRNA interaction is essential for maintaining pancreatic beta-cell function and insulin secretion (PubMed: 21880712). Furthermore, the HIPK3 gene also produces a circular RNA (circHIPK3) that acts as a sponge for these same miRNAs, thereby indirectly protecting the mRNA 3′UTR from repression (PubMed: 30033884). Consequently, the HIPK3 mRNA 3′UTR is an emerging focal point for RNA-targeted therapeutic strategies, including the use of antisense oligonucleotides (ASOs) and miRNA mimics designed to modulate HIPK3 levels for treating cancer and metabolic disorders.

Other names

HIPK3 3'UTRDYRK6 mRNA 3'UTRFIST3 mRNA 3'UTRPKY mRNA 3'UTRHomeodomain-interacting protein kinase 3 3-prime untranslated region

Binding of microRNA mimics or antisense oligonucleotides to the 3′UTR to induce mRNA degradation or prevent translation of the HIPK3 protein.