HOMER2 pseudogene 1 (HOMER2P1)

HOMER2 pseudogene 1 (HOMER2P1) is a genomic locus related to the protein-coding gene *HOMER2*, which encodes a postsynaptic density scaffolding protein involved in synaptic signaling and calcium homeostasis[1][2][4][5]. However, *HOMER2 pseudogene 1* itself is classified as a **pseudogene**, meaning it does not produce a functional protein. Two related pseudogenes of *HOMER2* are mentioned in the human genome[1][2]. Pseudogenes arise through gene duplication or retrotransposition and accumulate mutations that render them non-functional. As such, HOMER2P1 lacks therapeutic or biomarker relevance and should not be considered a drug target. If you are interested in the active, protein-coding **HOMER2** gene itself (not the pseudogene), this gene encodes a postsynaptic scaffolding protein implicated in the regulation of glutamatergic signaling, hearing function, synaptic plasticity, and possibly in neuroprotection and apoptosis through scaffold interactions with multiple synaptic proteins[1][2][3][4][5]. However, *HOMER2P1* as a pseudogene lacks these properties. **HOMER2 pseudogene 1** (HOMER2P1) is not a druggable or functional target, but a non-coding pseudogene with no direct biological, pathological, or therapeutic significance. This query most likely results from a confusion with the functional HOMER2 scaffold protein gene.

Other names

HOMER2P1HOMER2 pseudogene 1