Homo sapiens microRNA 130b-3p (hsa-miR-130b-3p) (hsa-miR-130b-3p)

hsa-miR-130b-3p is a mature microRNA sequence that functions as a critical post-transcriptional regulator of gene expression in humans (miRBase, MIMAT0000691). It modulates essential biological processes, including cell proliferation, apoptosis, and angiogenesis, by binding to the 3' untranslated regions (UTRs) of target messenger RNAs such as PTEN, CHD9, and KLF4 (NIH, PMID: 38003433). In oncology, hsa-miR-130b-3p frequently acts as an oncomir, promoting tumor progression and metastasis in colorectal cancer and glioma, although it can also function as a tumor suppressor in specific contexts like breast cancer (NIH, PMID: 38035044). Beyond cancer, its dysregulation is implicated in metabolic and neurodegenerative conditions, such as diabetic encephalopathy and polycystic ovary syndrome (JensenLab, PMID: 37521866). As a potential therapeutic target, research focuses on using synthetic inhibitors (antagomirs) or mimics to restore normal gene expression patterns in disease states (CAS.org). However, clinical translation faces significant hurdles, including the need for efficient delivery systems and the mitigation of off-target toxicity (NIH, PMID: 35326397).

Other names

miR-130bhsa-miR-130bMIMAT0000691microRNA 130b

Synthetic inhibitors such as antagomirs bind to the mature miRNA sequence to prevent its interaction with target mRNAs, while mimics or agomirs replenish miRNA levels to enhance the silencing of specific oncogenic or pathological transcripts.