Homo sapiens microRNA 3184-3p (hsa-miR-3184-3p)

hsa-miR-3184-3p is a mature microRNA sequence that serves as a post-transcriptional regulator of gene expression by binding to the 3' untranslated regions (UTRs) of target messenger RNAs. In clinical research, it has been identified as a significant factor in the progression of glioma, where it is found enriched in cerebrospinal fluid (CSF) exosomes. Within the tumor microenvironment, it promotes oncogenic processes such as cell proliferation, migration, and invasion while simultaneously inhibiting apoptosis. Furthermore, it contributes to immune evasion by polarizing macrophages toward an immunosuppressive M2-like phenotype, specifically by targeting the RSAD2 gene. Beyond oncology, hsa-miR-3184-3p has been noted for its altered expression in neurodegenerative conditions like Parkinson's disease, highlighting its potential as a non-invasive biomarker. Therapeutic strategies aimed at this molecule involve the use of antagomirs to silence its activity in disease states where it is overexpressed.

Other names

miR-3184-3phsa-miR-3184MIR3184MicroRNA 3184

Binds to the 3' untranslated region (UTR) of target mRNAs to induce translational repression or mRNA degradation.