Homo sapiens microRNA 4262 (hsa-miR-4262)

hsa-miR-4262 is a mature microRNA that serves as a key post-transcriptional regulator of gene expression in humans by binding to the 3-untranslated regions (UTRs) of target messenger RNAs (1.1.3, 1.1.5). It is involved in a variety of essential biological processes, including cell proliferation, invasion, apoptosis, and cell cycle regulation (1.1.2, 1.3.1). In clinical contexts, hsa-miR-4262 is frequently associated with cancer progression, where it can act as an oncomiR by targeting tumor suppressors such as KLF6, KLF15, and PTEN (1.1.2, 1.3.1, 1.3.4). It has been implicated in the pathogenesis of breast cancer, gastric cancer, melanoma, and non-small cell lung cancer, and is notably linked to paclitaxel resistance (1.1.2, 1.3.1, 1.3.2). Furthermore, hsa-miR-4262 is being explored as a diagnostic biomarker, particularly in its exosomal form for brain tumors and heart failure (1.1.1, 1.2.1). Therapeutic strategies targeting this molecule include the use of miRNA mimics for restoration or antagomiRs for inhibition, though challenges remain regarding delivery and off-target effects (1.1.3, 1.1.5).

Other names

miR-4262hsa-mir-4262MicroRNA 4262mature hsa-miR-4262

Post-transcriptional gene silencing of target mRNAs (such as KLF6, KLF15, PTEN, and LATS1) through sequence-specific binding to the 3-untranslated region (UTR), which leads to mRNA degradation or translational repression (1.1.3, 1.3.1, 1.3.4).