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Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein (HERPUD2)
- Target
- HERPUD2
- Molecular classification
- Other (ER membrane scaffold protein, UBL domain protein)
01
Overview
HERPUD2, also known as HERP2, is a membrane protein located predominantly in the endoplasmic reticulum (ER) of human cells and contains a ubiquitin-like (UBL) domain at its N-terminus[1][2]. It is homologous to HERPUD1 (HERP1) and participates in protein quality control by regulating ER-associated degradation (ERAD), assisting in the removal of misfolded or aberrant proteins from the ER[1]. HERPUD2 is constitutively expressed, unlike HERP1, which is strongly upregulated by ER stress[1]. HERPUD2 acts as a scaffold in the HRD1/SEL1L ubiquitin ligase complex, promoting degradation of both glycosylated and non-glycosylated ERAD substrates by recruiting DERL2 to the ERAD machinery; this function is essential for normal protein homeostasis but there is no evidence of direct therapeutic targeting or drug interaction with HERPUD2[1][2][3].
- Other names
- HERP2FLJ22313homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 2
02
Biological functions
Endoplasmic reticulum-associated degradation (ERAD)Protein quality controlUnfolded protein response (predicted)
03
Disease associations
Other (no clear evidence implicating direct involvement in specific disease classes, but involved in ER stress response and protein degradation homeostasis)
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